Journal Articles

Korte BG, Giese MA, Ramakrishnan G, Ma S, Bennin D, Rindy J, Dewey CN, Huttenlocher A. Cell Type-Specific Transcriptome Profiling Reveals a Role for Thioredoxin During Tumor Initiation. Front Immunol. 2022 Feb 17.

Miskolci V, Tweed KE, Lasarev MR, Britt EC, Walsh AJ, Zimmerman LJ, McDougal CE, Cronan MR, Fan J, Sauer JD, Skala MC, Huttenlocher A. In vivo fluorescence lifetime imaging of macrophage intracellular metabolism during wound responses in zebrafish. Elife. 2022 Feb 24

Klemm LC, Denu RA, Hind LE, Rocha-Gregg BL, Burkard ME, Huttenlocher A. Centriole and Golgi microtubule nucleation are dispensable for the migration of human neutrophil-like cells. Mol Biol Cell. 2021 Aug 15.

Horton MV, Johnson CJ, Zarnowski R, Andes BD, Schoen TJ, Kernien JF, Lowman D, Kruppa MD, Ma Z, Williams DL, Huttenlocher A, Nett JE. Candida auris Cell Wall Mannosylation Contributes to Neutrophil Evasion through Pathways Divergent from Candida albicans and Candida glabrata. mSphere. 2021 Jun 30.

Houseright RA, Miskolci V, Mulvaney O, Bortnov V, Mosher DF, Rindy J, Bennin DA, Huttenlocher A. Myeloid-derived growth factor regulates neutrophil motility in interstitial tissue damage. J Cell Biol. 2021 Aug 2

Hind LE, Giese MA, Schoen TJ, Beebe DJ, Keller N, Huttenlocher A. Immune Cell Paracrine Signaling Drives the Neutrophil Response to A. fumigatus in an Infection-on-a-Chip Model. Cell Mol Bioeng. 2020 Oct 13

Yu J, Piazza A, Sparks S, Hind LE, Niles DJ, Ingram PN, Huang W, Ricke WA, Jarrard DF, Huttenlocher A, Basu H, Beebe. A reconfigurable microscale assay enables insights into cancer-associated fibroblast modulation of immune cell recruitment. DJ.Integr Biol (Camb). 2021 Apr 20.

Majumder A, Suknuntha K, Bennin D, Klemm L, Brok-Volchanskaya VS, Huttenlocher A, Slukvin I. Generation of Human Neutrophils from Induced Pluripotent Stem Cells in Chemically Defined Conditions Using ETV2 Modified mRNA. STAR Protoc. 2020 Sep 18

Barros-Becker F, Squirrell JM, Burke R, Chini J, Rindy J, Karim A, Eliceiri KW, Gibson A, Huttenlocher A. Distinct Tissue Damage and Microbial Cues Drive Neutrophil and Macrophage Recruitment to Thermal Injury. iScience. 2020 Oct 22

Blachowicz A, Raffa N, Bok JW, Choera T, Knox B, Lim FY, Huttenlocher A, Wang CCC, Venkateswaran K, Keller NP. Contributions of Spore Secondary Metabolites to UV-C Protection and Virulence Vary in Different Aspergillus fumigatus Strains. mBio. 2020 Feb 18

Houseright RA, Rosowski EE, Lam PY, Tauzin SJM, Mulvaney O, Dewey CN, Huttenlocher A. Cell type specific gene expression profiling reveals a role for complement component C3 in neutrophil responses to tissue damage. Sci Rep. 2020 Sep 24

Bastos RW, Valero C, Silva LP, Schoen T, Drott M, Brauer V, Silva-Rocha R, Lind A, Steenwyk JL, Rokas A, Rodrigues F, Resendiz-Sharpe A, Lagrou K, Marcet-Houben M, Gabaldón T, McDonnell E, Reid I, Tsang A, Oakley BR, Loures FV, Almeida F, Huttenlocher A, Keller NP, Ries LNA, Goldman GH. Functional Characterization of Clinical Isolates of the Opportunistic Fungal Pathogen Aspergillus nidulans. mSphere. 2020 Apr 8

Golenberg N, Squirrell JM, Bennin DA, Rindy J, Pistono PE, Eliceiri KW, Shelef MA, Kang J, Huttenlocher A. Citrullination regulates wound responses and tissue regeneration in zebrafish. J Cell Biol. 2020 Apr 6.

de Oliveira S, Houseright RA, Korte BG, Huttenlocher A. DnaJ-PKAc fusion induces liver inflammation in a zebrafish model of Fibrolamellar Carcinoma. Dis Model Mech. 2020 Feb 26.

Blachowicz A, Raffa N, Bok JW, Choera T, Knox B, Lim FY, Huttenlocher A, Wang CCC, Venkateswaran K, Keller NP. Contributions of Spore Secondary Metabolites to UV-C Protection and Virulence Vary in Different Aspergillus fumigatus Strains. mBio. 2020 Feb 18.

Rosowski EE, He J, Huisken J, Keller NP, Huttenlocher A. Efficacy of Voriconazole against Aspergillus fumigatus Infection Depends on Host Immune Function. Antimicrob Agents Chemother. 2020 Jan 27;64(2). pii: e00917-19. doi: 10.1128/AAC.00917-19. Print 2020 Jan 27.

Schoen TJ, Rosowski EE, Knox BP, Bennin D, Keller NP, Huttenlocher A. Neutrophil phagocyte oxidase activity controls invasive fungal growth and inflammation in zebrafish. J Cell Sci. 2019 Dec 20;133(5). pii: jcs236539. doi: 10.1242/jcs.236539.

Brok-Volchanskaya VS, Bennin DA, Suknuntha K, Klemm LC, Huttenlocher A, Slukvin I. Effective and Rapid Generation of Functional Neutrophils from Induced Pluripotent Stem Cells Using ETV2-Modified mRNA. Stem Cell Reports. 2019 Dec 10;13(6):1099-1110. doi: 10.1016/j.stemcr.2019.10.007.

McMinn PH, Hind LE, Huttenlocher A, Beebe DJ. Neutrophil trafficking on-a-chip: an in vitro, organotypic model for investigating neutrophil priming, extravasation, and migration with spatiotemporal control. Lab Chip. 2019 Nov 7;19(21):3697-3705. doi: 10.1039/c9lc00562e.

Miskolci V, Squirrell J, Rindy J, Vincent W, Sauer JD, Gibson A, Eliceiri KW, Huttenlocher A.
Distinct inflammatory and wound healing responses to complex caudal fin injuries of
larval zebrafish.
Elife. 2019 Jul 1;8.

de Oliveira S, Houseright RA, Graves AL, Golenberg N, Korte BG, Miskolci V, Huttenlocher A.
Metformin modulates innate immune-mediated inflammation and early progression of
NAFLD-associated hepatocellular carcinoma in zebrafish.

J Hepatol. 2019 Apr;70(4):710-721.

Powell D, Lou M, Barros Becker F, Huttenlocher A. Cxcr1 mediates recruitment of
neutrophils and supports proliferation of tumor-initiating astrocytes in vivo.
Sci Rep. 2018 Sep 5;8(1):13285.

Hind LE, Ingram PN, Beebe DJ, Huttenlocher A. Interaction with an endothelial
lumen increases neutrophil lifetime and motility in response to P aeruginosa.
Blood. 2018 Oct 25;132(17):1818-1828.

Johnson CJ, Davis JM, Huttenlocher A, Kernien JF, Nett JE. Emerging Fungal
Pathogen Candida auris Evades Neutrophil Attack.
MBio. 2018 Aug 21;9(4).

Rosowski EE, Raffa N, Knox BP, Golenberg N, Keller NP, Huttenlocher A. Macrophages
inhibit Aspergillus fumigatus germination and neutrophil-mediated fungal killing.
PLoS Pathog. 2018 Aug 2;14(8):e1007229.

Jain S, Sekonyela R, Knox BP, Palmer JM, Huttenlocher A, Kabbage M, Keller NP. Selenate
sensitivity of a laeA mutant is restored by overexpression of the bZIP protein MetR in
Aspergillus fumigatus.
Fungal Genet Biol. 2018 Aug;117:1-10.

Ingram PN, Hind LE, Jiminez-Torres JA, Huttenlocher A, Beebe DJ. An Accessible Organotypic
Microvessel Model Using iPSC-Derived Endothelium.

Adv Healthc Mater. 2018 Jan;7(2). doi: 10.1002/adhm.201700497.

LeBert D, Squirrell JM, Freisinger C, Rindy J, Golenberg N, Frecentese G, Gibson A,
Eliceiri KW, Huttenlocher A. Damage-induced reactive oxygen species regulate
and dynamic collagen-based projections to mediate
wound repair.
Elife. 2018 Jan 16;7. pii: e30703.

Barros-Becker F, Lam PY, Fisher R, Huttenlocher A. Live imaging reveals
distinct modes of neutrophil and macrophage migration within interstitial tissues.
J Cell Sci. 2017 Nov 15;130(22):3801-3808.

Vincent WJB, Harvie EA, Sauer JD, Huttenlocher A. Neutrophil derived LTB4 induces
macrophage aggregation in response to encapsulated Streptococcus iniae infection.
PLoS One. 2017 Jun 28;12(6):e0179574.

Knox BP, Huttenlocher A, Keller NP. Real-time visualization of immune cell
clearance of Aspergillus fumigatus spores and hyphae.
Fungal Genet Biol.
2017 Aug;105:52-54.

Rosowski EE, Deng Q, Keller NP, Huttenlocher A. Rac2 Functions in Both
Neutrophils and Macrophages To Mediate Motility and Host Defense in Larval
Zebrafish. J Immunol. 2016 Dec 15;197(12):4780-4790.

Knox BP, Blachowicz A, Palmer JM, Romsdahl J, Huttenlocher A, Wang CC, Keller
NP, Venkateswaran K. Characterization of Aspergillus fumigatus Isolates from Air
and Surfaces of the International Space Station. mSphere. 2016 Oct 26;1(5). pii:

Huemer K, Squirrell JM, Swader R, LeBert DC, Huttenlocher A, Eliceiri KW.
zWEDGI: Wounding and Entrapment Device for Imaging Live Zebrafish Larvae.
Zebrafish. 2017 Feb;14(1):42-50. doi: 10.1089/zeb.2016.1323.

Davis JM, Huang M, Botts MR, Hull CM, Huttenlocher A. A Zebrafish Model of
Cryptococcal Infection Reveals Roles for Macrophages, Endothelial Cells, and
Neutrophils in the Establishment and Control of Sustained Fungemia. Infect Immun.
2016 Sep 19;84(10):3047-62. doi: 10.1128/IAI.00506-16.

LeBert DC, Squirrell JM, Huttenlocher A, Eliceiri KW. Second harmonic
generation microscopy in zebrafish. Methods Cell Biol. 2016;133:55-68. doi:

Boateng LR, Bennin D, De Oliveira S, Huttenlocher A. Mammalian Actin-binding
Protein-1/Hip-55 Interacts with FHL2 and Negatively Regulates Cell Invasion. J
Biol Chem. 2016 Jul 1;291(27):13987-98. doi: 10.1074/jbc.M116.725739.

Moussavi-Harami SF, Mladinich KM, Sackmann EK, Shelef MA, Starnes TW,
Guckenberger DJ, Huttenlocher A, Beebe DJ. Microfluidic device for simultaneous
analysis of neutrophil extracellular traps and production of reactive oxygen
species. Integr Biol (Camb). 2016 Feb;8(2):243-52. doi: 10.1039/c5ib00225g.

Vincent WJ, Freisinger CM, Lam PY, Huttenlocher A, Sauer JD. Macrophages
mediate flagellin induced inflammasome activation and host defense in zebrafish.
Cell Microbiol. 2016 Apr;18(4):591-604. doi: 10.1111/cmi.12536.

Yamahashi Y, Cavnar PJ, Hind LE, Berthier E, Bennin DA, Beebe D, Huttenlocher A.
Integrin associated proteins differentially regulate neutrophil polarity and
directed migration in 2D and 3D. Biomed Microdevices. 2015 Oct;17(5):100. doi:

LeBert DC, Squirrell JM, Rindy J, Broadbridge E, Lui Y, Zakrzewska A,
Eliceiri KW, Meijer AH, Huttenlocher A. Matrix metalloproteinase 9 modulates
collagen matrices and wound repair. Development. 2015 Jun 15;142(12):2136-46.
doi: 10.1242/dev.121160.

Harvie EA, Huttenlocher A. Non-invasive Imaging of the Innate Immune Response
in a Zebrafish Larval Model of Streptococcus iniae Infection. J Vis Exp. 2015 Apr
21;(98). doi: 10.3791/52788.

Lam PY, Mangos S, Green JM, Reiser J, Huttenlocher A. In vivo imaging and
characterization of actin microridges. PLoS One. 2015 Jan 28;10(1):e0115639. doi:

Tauzin S, Starnes TW, Becker FB, Lam PY, Huttenlocher A. Redox and Src family
kinase signaling control leukocyte wound attraction and neutrophil reverse
migration. J Cell Biol. 2014 Dec 8;207(5):589-98. doi: 10.1083/jcb.201408090.

Freisinger CM, Huttenlocher A. Live imaging and gene expression analysis in
zebrafish identifies a link between neutrophils and epithelial to mesenchymal
transition. PLoS One. 2014 Nov 5;9(11):e112183. doi: 10.1371/journal.pone.0112183.

Shelef MA, Bennin DA, Yasmin N, Warner TF, Ludwig T, Beggs HE, Huttenlocher A.
Focal adhesion kinase is required for synovial fibroblast invasion, but not
murine inflammatory arthritis. Arthritis Res Ther. 2014 Oct 4;16(5):464. doi:

Knox BP, Deng Q, Rood M, Eickhoff JC, Keller NP, Huttenlocher A. Distinct
innate immune phagocyte responses to Aspergillus fumigatus conidia and hyphae in
zebrafish larvae. Eukaryot Cell. 2014 Oct;13(10):1266-77. doi:

Lam PY, Fischer RS, Shin WD, Waterman CM, Huttenlocher A. Spinning disk
confocal imaging of neutrophil migration in zebrafish. Methods Mol Biol.
2014;1124:219-33. doi: 10.1007/978-1-62703-845-4_14.

Shelef MA, Sokolove J, Lahey LJ, Wagner CA, Sackmann EK, Warner TF, Wang Y,
Beebe DJ, Robinson WH, Huttenlocher A. Peptidylarginine deiminase 4 contributes
to tumor necrosis factor α-induced inflammatory arthritis. Arthritis Rheumatol.
2014 Jun;66(6):1482-91. doi: 10.1002/art.38393.

Starnes TW, Bennin DA, Bing X, Eickhoff JC, Grahf DC, Bellak JM, Seroogy CM,
Ferguson PJ, Huttenlocher A. The F-BAR protein PSTPIP1 controls extracellular
matrix degradation and filopodia formation in macrophages. Blood. 2014 Apr
24;123(17):2703-14. doi: 10.1182/blood-2013-07-516948.

Lam PY, Harvie EA, Huttenlocher A. Heat shock modulates neutrophil motility
in zebrafish. PLoS One. 2013 Dec 19;8(12):e84436. doi: 10.1371/journal.pone.0084436.

Wiemer AJ, Wernimont SA, Cung TD, Bennin DA, Beggs HE, Huttenlocher A. The
focal adhesion kinase inhibitor PF-562,271 impairs primary CD4+ T cell
activation. Biochem Pharmacol. 2013 Sep 15;86(6):770-81. doi:

Bischel LL, Mader BR, Green JM, Huttenlocher A, Beebe DJ. Zebrafish
Entrapment By Restriction Array (ZEBRA) device: a low-cost, agarose-free
zebrafish mounting technique for automated imaging. Lab Chip. 2013 May
7;13(9):1732-6. doi: 10.1039/c3lc50099c.

Deng Q, Sarris M, Bennin DA, Green JM, Herbomel P, Huttenlocher A. Localized
bacterial infection induces systemic activation of neutrophils through Cxcr2
signaling in zebrafish. J Leukoc Biol. 2013 May;93(5):761-9. doi: 10.1189/jlb.1012534.

Shelef MA, Bennin DA, Mosher DF, Huttenlocher A. Citrullination of
fibronectin modulates synovial fibroblast behavior. Arthritis Res Ther. 2012 Nov
5;14(6):R240. doi: 10.1186/ar4083.

Harvie EA, Green JM, Neely MN, Huttenlocher A. Innate immune response to
Streptococcus iniae infection in zebrafish larvae. Infect Immun. 2013
Jan;81(1):110-21. doi: 10.1128/IAI.00642-12.

Yoo SK, Freisinger CM, LeBert DC, Huttenlocher A. Early redox, Src family
kinase, and calcium signaling integrate wound responses and tissue regeneration
in zebrafish. J Cell Biol. 2012 Oct 15;199(2):225-34. doi: 10.1083/jcb.201203154.

Yoo SK, Lam PY, Eichelberg MR, Zasadil L, Bement WM, Huttenlocher A. The role
of microtubules in neutrophil polarity and migration in live zebrafish. J Cell
Sci. 2012 Dec 1;125(Pt 23):5702-10. doi: 10.1242/jcs.108324.

Lam PY, Yoo SK, Green JM, Huttenlocher A. The SH2-domain-containing inositol
5-phosphatase (SHIP) limits the motility of neutrophils and their recruitment to
wounds in zebrafish. J Cell Sci. 2012 Nov 1;125(Pt 21):4973-8. doi: 10.1242/jcs.106625.

Cavnar PJ, Mogen K, Berthier E, Beebe DJ, Huttenlocher A. The actin
regulatory protein HS1 interacts with Arp2/3 and mediates efficient neutrophil
chemotaxis. J Biol Chem. 2012 Jul 20;287(30):25466-77. doi: 10.1074/jbc.M112.364562.

Boateng LR, Cortesio CL, Huttenlocher A. Src-mediated phosphorylation of
mammalian Abp1 (DBNL) regulates podosome rosette formation in transformed
fibroblasts. J Cell Sci. 2012 Mar 1;125(Pt 5):1329-41. doi: 10.1242/jcs.096529.

Deng Q, Harvie EA, Huttenlocher A. Distinct signalling mechanisms mediate
neutrophil attraction to bacterial infection and tissue injury. Cell Microbiol.
2012 Apr;14(4):517-28. doi: 10.1111/j.1462-5822.2011.01738.x.

Yoo SK, Starnes TW, Deng Q, Huttenlocher A. Lyn is a redox sensor that
mediates leukocyte wound attraction in vivo. Nature. 2011 Nov
20;480(7375):109-12. doi: 10.1038/nature10632.

Wernimont SA, Wiemer AJ, Bennin DA, Monkley SJ, Ludwig T, Critchley DR,
Huttenlocher A. Contact-dependent T cell activation and T cell stopping require
talin1. J Immunol. 2011 Dec 15;187(12):6256-67. doi: 10.4049/jimmunol.1102028.

Deng Q, Yoo SK, Cavnar PJ, Green JM, Huttenlocher A. Dual roles for Rac2 in
neutrophil motility and active retention in zebrafish hematopoietic tissue. Dev
Cell. 2011 Oct 18;21(4):735-45. doi: 10.1016/j.devcel.2011.07.013.

Wiemer AJ, Wernimont S, Huttenlocher A. Live imaging of LFA-1-dependent
T-cell motility and stop signals. Methods Mol Biol. 2012;757:191-204. doi:

Wiemer AJ, Hegde S, Gumperz JE, Huttenlocher A. A live imaging cell motility
screen identifies prostaglandin E2 as a T cell stop signal antagonist. J Immunol.
2011 Oct 1;187(7):3663-70. doi: 10.4049/jimmunol.1100103

Starnes TW, Cortesio CL, Huttenlocher A. Imaging podosome dynamics and matrix
degradation. Methods Mol Biol. 2011;769:111-36. doi: 10.1007/978-1-61779-207-6_9.

Cavnar PJ, Berthier E, Beebe DJ, Huttenlocher A. Hax1 regulates neutrophil
adhesion and motility through RhoA. J Cell Biol. 2011 May 2;193(3):465-73. doi:

Cortesio CL, Boateng LR, Piazza TM, Bennin DA, Huttenlocher A.
Calpain-mediated proteolysis of paxillin negatively regulates focal adhesion
dynamics and cell migration. J Biol Chem. 2011 Mar 25;286(12):9998-10006. doi:

Yoo SK, Huttenlocher A. Spatiotemporal photolabeling of neutrophil
trafficking during inflammation in live zebrafish. J Leukoc Biol. 2011
May;89(5):661-7. doi: 10.1189/jlb.1010567.

Wernimont SA, Legate KR, Simonson WT, Fassler R, Huttenlocher A. PIPKI gamma
90 negatively regulates LFA-1-mediated adhesion and activation in antigen-induced
CD4+ T cells. J Immunol. 2010 Oct 15;185(8):4714-23. doi: 10.4049/jimmunol.1001445.

Walters KB, Green JM, Surfus JC, Yoo SK, Huttenlocher A. Live imaging of
neutrophil motility in a zebrafish model of WHIM syndrome. Blood. 2010 Oct
14;116(15):2803-11. doi: 10.1182/blood-2010-03-276972.

Cortesio CL, Wernimont SA, Kastner DL, Cooper KM, Huttenlocher A. Impaired
podosome formation and invasive migration of macrophages from patients with a
PSTPIP1 mutation and PAPA syndrome. Arthritis Rheum. 2010 Aug;62(8):2556-8. doi:

Wernimont SA, Simonson WT, Greer PA, Seroogy CM, Huttenlocher A. Calpain 4 is
not necessary for LFA-1-mediated function in CD4+ T cells. PLoS One. 2010 May
7;5(5):e10513. doi: 10.1371/journal.pone.0010513.

Yoo SK, Deng Q, Cavnar PJ, Wu YI, Hahn KM, Huttenlocher A. Differential
regulation of protrusion and polarity by PI3K during neutrophil motility in live
zebrafish. Dev Cell. 2010 Feb 16;18(2):226-36. doi: 10.1016/j.devcel.2009.11.015.
Erratum in: Dev Cell. 2011 Aug 16;21(2):384.

Chan KT, Bennin DA, Huttenlocher A. Regulation of adhesion dynamics by
calpain-mediated proteolysis of focal adhesion kinase (FAK). J Biol Chem. 2010
Apr 9;285(15):11418-26. doi: 10.1074/jbc.M109.090746.

Cortesio CL, Perrin BJ, Bennin DA, Huttenlocher A. Actin-binding protein-1
interacts with WASp-interacting protein to regulate growth factor-induced dorsal
ruffle formation. Mol Biol Cell. 2010 Jan 1;21(1):186-97. doi: 10.1091/mbc.E09-02-0106.

Wiemer AJ, Lokuta MA, Surfus JC, Wernimont SA, Huttenlocher A. Calpain
inhibition impairs TNF-alpha-mediated neutrophil adhesion, arrest and oxidative
burst. Mol Immunol. 2010 Jan;47(4):894-902. doi: 10.1016/j.molimm.2009.10.002.

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