What are the mechanisms that regulate innate immunity and the onset and resolution of inflammation? How do wounds heal and how is wound healing altered in disease? How do neutrophils, and cross talk with macrophages, regulate tissue damage and repair in sterile injury, infected tissues and cancer (a type of “unhealed wound”)? Our research is aimed at understanding the cellular and molecular mechanisms that regulate cell migration and wound healing using biochemical genetic and imaging approaches. We use state of the art live imaging, biosensors and photomanipulation to examine and control polarity of cell signaling during cell migration in live animals and understand how these mechanisms are altered in tissue damage and repair.
LeBert D, Squirrell JM, Freisinger C, Rindy J, Golenberg N, Frecentese G, Gibson A, Eliceiri KW, Huttenlocher A. Damage-induced reactive oxygen species regulate vimentin and dynamic collagen-based projections to mediate wound repair. Elife. 2018 Jan 16;7. …February 23, 2018
Barros-Becker F, Lam PY, Fisher R, Huttenlocher A. Live imaging reveals distinct modes of neutrophil and macrophage migration within interstitial tissues. J Cell Sci. 2017 Nov 15;130(22):3801-3808.February 2, 2018
Powell D, Tauzin S, Hind LE, Deng Q, Beebe DJ, Huttenlocher A. Chemokine Signaling and the Regulation of Bidirectional Leukocyte Migration in Interstitial Tissues. Cell Rep. 2017 May 23;19(8):1572-1585.June 9, 2017
Rosowski EE, Deng Q, Keller NP, Huttenlocher A. Rac2 Functions in Both Neutrophils and Macrophages To Mediate Motility and Host Defense in Larval Zebrafish. J Immunol. 2016 Dec 15;197(12):4780-4790.April 25, 2017
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