What are the mechanisms that regulate the migration of leukocytes into areas of inflammation? How do tumor cells invade and metastasize? Cell migration plays a central role in many different disease processes including cancer, heart disease, asthma and arthritis. Insight into the mechanisms that regulate cell migration will contribute to our understanding of basic cellular processes, but will also lead to the development of new therapeutic approaches for a wide variety of medical conditions.
Our research is aimed at understanding the cellular and molecular mechanisms that regulate cell migration using biochemical genetic and imaging approaches. We use state of the art live imaging, biosensors and photomanipulation to examine and control polarity of cell signaling during cell migration in live animals. We also examine host-pathogen interactions in zebrafish.
LeBert D, Squirrell JM, Freisinger C, Rindy J, Golenberg N, Frecentese G, Gibson A, Eliceiri KW, Huttenlocher A. Damage-induced reactive oxygen species regulate vimentin and dynamic collagen-based projections to mediate wound repair. Elife. 2018 Jan 16;7. …February 23, 2018
Barros-Becker F, Lam PY, Fisher R, Huttenlocher A. Live imaging reveals distinct modes of neutrophil and macrophage migration within interstitial tissues. J Cell Sci. 2017 Nov 15;130(22):3801-3808.February 2, 2018
Powell D, Tauzin S, Hind LE, Deng Q, Beebe DJ, Huttenlocher A. Chemokine Signaling and the Regulation of Bidirectional Leukocyte Migration in Interstitial Tissues. Cell Rep. 2017 May 23;19(8):1572-1585.June 9, 2017
Rosowski EE, Deng Q, Keller NP, Huttenlocher A. Rac2 Functions in Both Neutrophils and Macrophages To Mediate Motility and Host Defense in Larval Zebrafish. J Immunol. 2016 Dec 15;197(12):4780-4790.April 25, 2017
Knox BP, Blachowicz A, Palmer JM, Romsdahl J, Huttenlocher A, Wang CC, Keller NP, Venkateswaran K. Characterization of Aspergillus fumigatus Isolates from Air and Surfaces of the International Space Station. mSphere. 2016 Oct 26;1(5). pii: …April 25, 2017
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We hare happy to announce that two lab members have join our lab. Russell Burke will join as a postdoctoral associate, and Taylor Schoen as a graduate student. Welcome!August 30, 2018
CMB student, Morgan Giese, has join the Huttenlocher lab! Welcome Morgan!February 23, 2018
We have a new PhD in the Huttenlocher Lab! Dr. Will Vincent gave a great thesis defense yesterday! Congrats Will!May 16, 2017
Netta is our new March Madness bracket champ! Way to go! Emily, on the other side firmly grasps the Toilett Bowl this year!April 28, 2017
Congratulations for Danny LeBert and Will Vincent! Both accepted teaching positions at Shenandoah University and St. Johnsbury School, respectively.April 28, 2017
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