What are the mechanisms that regulate the migration of leukocytes into areas of inflammation? How do tumor cells invade and metastasize? Cell migration plays a central role in many different disease processes including cancer, heart disease, asthma and arthritis. Insight into the mechanisms that regulate cell migration will contribute to our understanding of basic cellular processes, but will also lead to the development of new therapeutic approaches for a wide variety of medical conditions.
Our research is aimed at understanding the cellular and molecular mechanisms that regulate cell migration using biochemical genetic and imaging approaches. We use state of the art live imaging, biosensors and photomanipulation to examine and control polarity of cell signaling during cell migration in live animals. We also examine host-pathogen interactions in zebrafish.
LeBert D, Squirrell JM, Freisinger C, Rindy J, Golenberg N, Frecentese G, Gibson A, Eliceiri KW, Huttenlocher A. Damage-induced reactive oxygen species regulate vimentin and dynamic collagen-based projections to mediate wound repair. Elife. 2018 Jan 16;7. …February 23, 2018
Barros-Becker F, Lam PY, Fisher R, Huttenlocher A. Live imaging reveals distinct modes of neutrophil and macrophage migration within interstitial tissues. J Cell Sci. 2017 Nov 15;130(22):3801-3808.February 2, 2018
Powell D, Tauzin S, Hind LE, Deng Q, Beebe DJ, Huttenlocher A. Chemokine Signaling and the Regulation of Bidirectional Leukocyte Migration in Interstitial Tissues. Cell Rep. 2017 May 23;19(8):1572-1585.June 9, 2017
Rosowski EE, Deng Q, Keller NP, Huttenlocher A. Rac2 Functions in Both Neutrophils and Macrophages To Mediate Motility and Host Defense in Larval Zebrafish. J Immunol. 2016 Dec 15;197(12):4780-4790.April 25, 2017
Knox BP, Blachowicz A, Palmer JM, Romsdahl J, Huttenlocher A, Wang CC, Keller NP, Venkateswaran K. Characterization of Aspergillus fumigatus Isolates from Air and Surfaces of the International Space Station. mSphere. 2016 Oct 26;1(5). pii: …April 25, 2017
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We have a new member of the Huttenlocher Lab! Welcome to Youtao who joins us as a postdoctoral fellow.August 16, 2019
On June 25th Francisco defended his thesis. Great work!!August 16, 2019
Netta defended her thesis on June 25 and did an amazing job!!August 16, 2019
The Huttenlocher Lab is looking for new postdoc candidates. If you are interested go to jobs.wisc.edu/research for more informationFebruary 6, 2019
Ashley Peterson, a new student Comparative Biomedical Sciences Graduate Program, has join the Huttenlocher Lab. Welcome!December 5, 2018
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