Drawn zebrafish with watercolors

What are the mechanisms that regulate innate immunity and the onset and resolution of inflammation?  How do wounds heal and how is wound healing altered in disease? How do neutrophils, and cross talk with macrophages, regulate tissue damage and repair in sterile injury, infected tissues and cancer  (a type of “unhealed wound”)? Our research is aimed at understanding the cellular and molecular mechanisms that regulate cell migration and wound healing using biochemical genetic and imaging approaches. We use state of the art live imaging, biosensors and photomanipulation to examine and control polarity of cell signaling during cell migration in live animals and understand how these mechanisms are altered in tissue damage and repair.

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