In the Huttenlocher laboratory we strive to discover new cell biological mechanisms during inflammation and its resolution, and their implications to human disease. We aim to achieve these goals by forming a cohesive and interactive laboratory environment that is highly collaborative both within and outside our laboratory. We believe in scientific rigor and enjoy the unexpected result. We also strive to share our research findings with the community as quickly as possible through presentations at national and international meetings and by sharing our work through pre-print servers. Our overall goal is to have an inclusive and supportive research environment that fosters the creative pursuit of science and new discovery.
The goal of the Huttenlocher laboratory is to understand how cells migrate and communicate with other cells during inflammation, cancer and tissue repair. We work across disciplines to achieve these goals and take advantage of advanced live imaging, quantitative analysis and bioengineering systems to answer questions relevant to human disease. To achieve these goals, we use zebrafish amenable to real time imaging of cell migration and inflammation. We also use human iPS cells to engineer innate immune cells that are studied in organotypic models in vitro. Students and postdocs are encouraged to pursue challenging problems in biomedical research that address fundamental questions of interest.
LeBert D, Squirrell JM, Freisinger C, Rindy J, Golenberg N, Frecentese G, Gibson A, Eliceiri KW, Huttenlocher A. Damage-induced reactive oxygen species regulate vimentin and dynamic collagen-based projections to mediate wound repair. Elife. 2018 Jan 16;7. …February 23, 2018
Barros-Becker F, Lam PY, Fisher R, Huttenlocher A. Live imaging reveals distinct modes of neutrophil and macrophage migration within interstitial tissues. J Cell Sci. 2017 Nov 15;130(22):3801-3808.February 2, 2018
Powell D, Tauzin S, Hind LE, Deng Q, Beebe DJ, Huttenlocher A. Chemokine Signaling and the Regulation of Bidirectional Leukocyte Migration in Interstitial Tissues. Cell Rep. 2017 May 23;19(8):1572-1585.June 9, 2017
Rosowski EE, Deng Q, Keller NP, Huttenlocher A. Rac2 Functions in Both Neutrophils and Macrophages To Mediate Motility and Host Defense in Larval Zebrafish. J Immunol. 2016 Dec 15;197(12):4780-4790.April 25, 2017
- More Publications posts