Category: Publications

Aspergillus SppA can alter echinocandin susceptibility and neutrophil killing

The Aspergillus fumigatus C2-Domain Protein SppA is required for septal integrity and alters susceptibility to echinocandins and neutrophil killing during infection. Calise DG, Michaelis ML, Bok JW, Chen Z, Coon JJ, Huttenlocher A, Chadwick BJ, Keller NP.bioRxiv [Preprint]. 2026 Jul 20:2026.07.17.739181. doi: 10.64898/2026.07.17.739181.PMID: 42539235

Fibroblast response to burn injury

Fibroblast response to burn injury in larval zebrafish mirrors developmental maturation and is inhibited by infiltrating neutrophils. Horn A, Hou Y, Squirrell JM, Fister AM, Rindy J, Miskolci V, Schrope JH, Burke R, Dewey C, Eliceiri KW, Huttenlocher A.Development. 2026 Aug 1;153(15):dev205534. doi: 10.1242/dev.205534. Epub 2026 Aug 6.PMID: 42464766

Xylazine disrupts skin homeostasis

Evidence that xylazine disrupts skin homeostasis by acting on epithelial cells through the kappa opioid receptor. Robertson TF, Horn A, Smith FM, Huttenlocher A.Dis Model Mech. 2026 Mar 1;19(3):dmm052600. doi: 10.1242/dmm.052600. Epub 2026 Mar 31.PMID: 41788025 

mydgf regulates inflammatory fate and motility of neutrophils

The paracrine factor myeloid derived growth factor regulates the inflammatory fate and motility of human induced pluripotent stem cell-derived neutrophils. Smith FM, Schrope JH, Bennin DA, Horn A, Wagner AS, Hou Y, Stevens JJ, Giese MA, Dinh HQ, Huttenlocher A.J Immunol. 2026 Feb 9;215(2):vkaf364. doi: 10.1093/jimmun/vkaf364.PMID: 41764731 

Congratulations to Netta Golenberg and lab on the publication of our recent Journal of Cell Biology paper entitled “Citrullination regulates wound responses and tissue regeneration in zebrafish”

ROS and Vimentin participate in early wound repair signaling

LeBert D, Squirrell JM, Freisinger C, Rindy J, Golenberg N, Frecentese G, Gibson A, Eliceiri KW, Huttenlocher A. Damage-induced reactive oxygen species regulate vimentin and dynamic collagen-based projections to mediate wound repair. Elife. 2018 Jan 16;7. pii: e30703.

Neutrophil and Macrophage migration, in vivo!

Barros-Becker F, Lam PY, Fisher R, Huttenlocher A. Live imaging reveals distinct modes of neutrophil and macrophage migration within interstitial tissues. J Cell Sci. 2017 Nov 15;130(22):3801-3808.

Chemokine receptors control neutrophil wound response

Powell D, Tauzin S, Hind LE, Deng Q, Beebe DJ, Huttenlocher A. Chemokine Signaling and the Regulation of Bidirectional Leukocyte Migration in Interstitial Tissues. Cell Rep. 2017 May 23;19(8):1572-1585.

Rac2 functions in neutrophils and macrophages

Rosowski EE, Deng Q, Keller NP, Huttenlocher A. Rac2 Functions in Both Neutrophils and Macrophages To Mediate Motility and Host Defense in Larval Zebrafish. J Immunol. 2016 Dec 15;197(12):4780-4790.

Space microbes

Knox BP, Blachowicz A, Palmer JM, Romsdahl J, Huttenlocher A, Wang CC, Keller NP, Venkateswaran K. Characterization of Aspergillus fumigatus Isolates from Air and Surfaces of the International Space Station. mSphere. 2016 Oct 26;1(5). pii: e00227-16. eCollection 2016 Sep-Oct.