Aspergillus SppA can alter echinocandin susceptibility and neutrophil killing

The Aspergillus fumigatus C2-Domain Protein SppA is required for septal integrity and alters susceptibility to echinocandins and neutrophil killing during infection.

Calise DG, Michaelis ML, Bok JW, Chen Z, Coon JJ, Huttenlocher A, Chadwick BJ, Keller NP.bioRxiv [Preprint]. 2026 Jul 20:2026.07.17.739181. doi: 10.64898/2026.07.17.739181.PMID: 42539235